Begin forwarded message:

From: DREAM Challenges <contact@dreamchallenges.org>

Subject: Announcing: The Allen Institute Cell Lineage Reconstruction DREAM Challenge

Date: September 23, 2019 at 12:14:15 PM CDT

To: <stevens@ci.uchicago.edu>

Reply-To: DREAM Challenges <contact@dreamchallenges.org>

Share Tweet Forward Sept. 23, 2019 – To advance our understanding of development and disease in multicellular organisms, The Allen Institute has partnered with DREAM Challenges to mobilize a larger community for evaluating new optimal tree-building methods. Top performers in this Challenge will be announced at Hindsight 2020 - The Allen Institute Developmental Recording Symposium, taking place on March 3-5, 2020, in Seattle, Washington. Challenge Overview CRISPR-based molecular tools allow the reconstruction of cell lineages based on the phylogenetical analysis of DNA mutations induced by CRISPR during development. This enables cell lineage reconstruction for complex model organisms at single-cell resolution. The Allen Institute Cell Lineage Reconstruction Challenge will provide an unprecedented opportunity to rigorously examine the performance and robustness of lineage reconstruction algorithms across datasets, number of cells, and sizes of lineage trees.   This DREAM Challenge comprises three sub-challenges to reconstruct cell lineage trees using 1) experimental molecular data from lineages of less than 100 cells and a video-microscopy reconstructed tree as ground truth; 2) data from an in silico-generated tree of 1,000 cells; and 3) data from an in silico-generated tree of 10,000 cells. Data and scientific guidance for this challenge are being provided by IBM, University College London, Weizmann Institute, Caltech, and University of Washington. Timeline Registration Opens: September, 2019 Launch: Mid-October, 2019 Final Submissions: January, 2020 Winners Announced: March, 2020 Learn More Copyright © 2019 Sage Bionetworks, All rights reserved.  Your participation in Sage Bionetworks/DREAM competitions has placed you on this email list.  Our mailing address is:  Sage Bionetworks 2901 3rd Ave. #330 Seattle, WA  98121 Add us to your address book Want to change how you receive these emails? You can update your preferences or unsubscribe from this list.